Publications

 

  1. Interactions of hydrolyzed β-lactams with the L1 metallo-β-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products

P. Hinchliffe, K. Calvopiña, P. Rabe, M. F. Mojica, C. J. Schofield, G. I. Dmitrienko, R. A. Bonomo, A. J. Vila, J. Spencer

J. Biol. Chem, 2023, 299, 104606.

  1. Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2

X. Liu, R. Reinbold, S. Liu, R. A. Herold, P. Rabe, S. Duclos, R. B. Yadav, M. I. Abboud, S. Thieffine, F. A. Armstrong, L. Brewitz, C. J. Schofield

J. Biol. Chem, 2023, 299, 102873.

  1. Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane

N. Frank, J. Nugent, B. R. Shire, H. D. Pickford, P. Rabe, A. J. Sterling, T. Zarganes-Tzitzikas, T. Grimes, A. L. Thompson, R. C. Smith, C. J. Schofield, P. E. Brennan, F. Duarte, E. A. Anderson

Nature, 2022, 611, 721–726.

  1. Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase

P. Rabe, C. C. Walla, N. K. Goodyear, J. Welsh, R. Southwart, I. Clifton, J. D.S. Linyard, A. Tumber, T.D.W. Claridge, W. K. Myers, C. J. Schofield

J. Biol. Chem. 2022, 102249.

  1. Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors

R. Reinbold, I. C. Hvinden, P. Rabe, R. A. Herold, A. Finch, J. Wood, M. Morgan, M. Staudt, I. J. Clifton, F. A. Armstrong, J. S. O. McCullagh, J. Redmond, C. Bardella, M. I. Abboud, C. J. Schofield

Nat. Commun. 2022, 13, 4785.

  1. Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors

P. A. Lang, R. Raj, A. Tumber, C. T. Lohans, P. Rabe, C. V. Robinson, J. Brem, C. J. Schofield

Proc. Natl. Acad. Sci. USA. 2022, 119, e2117310119.

  1. An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography

A. Butryn, P. S. Simon, P. Aller, P. Hinchliffe, R. N. Massad, G. Leen, C. L. Tooke, I. Bogacz, I. Kim, A. Bhowmick, A. S. Brewster, N. E. Devenish, J. Brem, J. J. A. G. Kamps, P. A. Lang, P. Rabe, D. Axford, J. H. Beale, B. Davy, A. Ebrahim, J. Orlans, S. L. S. Storm, T. Zhou, S. Owada, R. Tanaka, K. Tono, G. Evans, R. L. Owen, F. A. Houle, N. K. Sauter, C. J. Schofield, J. Spencer, V. K. Yachandra, J. Yano, J. F. Kern, A. M. Orville

Nat. Commun. 2021, 12, 4461.

  1. Structural Basis of Metallo-β-lactamase Inhibition by N-Sulfamoylpyrrole-2-carboxylates

A. J. M. Farley, Y. Ermolovich, K. Calvopiña, P. Rabe, T. Panduwawala, J. Brem,  F. Björkling, C. J. Schofield

ACS Infect. Dis. 2021, 7, 1809–1817.

  1. X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis

P. Rabe, J. J. A. G. Kamps, K. D. Sutherlin, J. D. S. Linyard, P. Aller, C. C. Pham, H. Makita, I. Clifton, M. A. McDonough, T. M. Leissing, D. Shutin, P. A. Lang, A. Butryn, J. Brem, S. Gul, F. D. Fuller, In-Sik Kim, M. Hon Cheah, T. Fransson, A. Bhowmick, I. D. Young, L. O’Riordan, A. S. Brewster, I. Pettinati, M. Doyle, Y. Joti, S. Owada, K. Tono, A. Batyuk, M. S. Hunter, R. Alonso-Mori, U. Bergmann, R. L. Owen, N. K. Sauter, T. D. W. Claridge, C. V. Robinson, V. K. Yachandra, J. Yano, J. F. Kern, A. M. Orville, C. J. Schofield

Science Advances, 2021, 7, DOI: 10.1126/sciadv.abh0250.

  1. The Termite Fungal Cultivar Termitomyces Combines Diverse Enzymes and Oxidative Reactions for Plant Biomass Conversion

F. Schalk, C. Gostinčar, N. Kreuzenbeck, B. Schantz-Conlon, E. Sommerwerk, P. Rabe, I. Burkhardt, T. Krüger, O. Kniemeyer, A. Brakhage, N. Gunde-Cimerman, W. De Beer, J. Dickschat, M. Poulsen, C. Beemelmanns

mBio. 2021, 12, e03551-20.

  1. Faropenem reacts with serine and metallo-β-lactamases to give multiple products

A. Lucic, P. Hinchliffe, T. R Malla, C. L. Tooke, J. Brem, K. Calvopiña, C. T. Lohans, P. Rabe, M. A McDonough, T. Armistead, A. M Orville, J. Spencer, C. J Schofield

Eur. J. Med. Chem. 2021, 215, 113257.

  1. Anaerobic fixed-target serial crystallography

P. Rabe, J. H. Beale, A. Butryn, P. Aller, A. Dirr, P. A. Lang, D. N. Axford, S. B. Carr, T. M. Leissing, M. A. McDonough, B. Davy,b A. Ebrahim, J. Orlans, S. L. S. Storm, A. M. Orville, C. J. Schofield, R. L. Owen

IUCrJ. 2020, 7, 901-912.

  1. A terpene synthase-cytochrome P450 cluster in Dictyostelium discoideum produces a novel trisnorsesquiterpene

X. Chen, K. Luck, P. Rabe, C. Qd Dinh, G. Shaulsky, D. R Nelson, J. Gershenzon, J. S Dickschat, T. G Köllner, F. Chen

Elife. 2019, 8, e44352.

  1. Substrate promiscuity of enzymes from the sesquiterpene biosynthetic pathways from Artemisia annua and Tanacetum parthenium allows for novel combinatorial sesquiterpene production

A. Beyraghdar Kashkooli, A. van der Krol, P. Rabe, J. S. Dickschat, H. Bouwmeester

Metab. Eng. 2019, 54, 12-23.

  1. The EI-MS Fragmentation Mechanisms of Bacterial Sesquiterpenes and Diterpenes

J. Rinkel, P. Rabe, J. S. Dickschat

Eur. J. Org. Chem. 2019, 351-359.

  1. Two Diterpene Synthases for Spiroalbatene and Cembrene A from Allokutzneria albata

J. Rinkel, L. Lauterbach, P. Rabe, J. S. Dickschat

Angew. Chem. Int. Ed. 2018, 57, 3238-3241.

  1. Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis

P. Rabe, J. J. A. G. Kamps, C. J. Schofield, C. T. Lohans

Nat. Prod. Rep. 2018, 35, 735-756.

  1. 18-Hydroxydolabella-3,7-diene synthase – a diterpene synthase from Chitinophaga pinensis

J. S. Dickschat, J. Rinkel, P. Rabe, A. Beyraghdar Kashkooli, H. J. Bouwmeester

Beilstein J. Org. Chem. 2017, 13, 1770-1780.

  1. Mechanisms of the Diterpene Cyclases β-Pinacene Synthase from Dictyostelium discoideum and Hydropyrene Synthase from Streptomyces clavuligerus

J. Rinkel, P. Rabe, X. Chen, T. G. Köllner, F. Chen, J. S. Dickschat

Chem. Eur. J. 2017, 23, 10501-10505.

  1. The GATA-Type Transcription Factor Csm1 Regulates Conidiation and Secondary Metabolism in Fusarium fujikuroi

E.-M. Niehaus, J. Schumacher, I. Burkhardt, P. Rabe, M. Münsterkötter, U. Güldener, J. S. Dickschat, B. Tudzynski

Front. Microbiol. 2017, 8, 1175.

  1. Isoafricanol synthase from Streptomyces malaysiensis

P. Rabe, M. Samborskyy, P. F. Leadlay, J. S. Dickschat

Org. Biomol. Chem. 2017, 15, 2353-2358.

  1. Mechanistic Investigations of Two Bacterial Diterpene Cyclases: Spiroviolene Synthase and Tsukubadiene Synthase

P. Rabe, J. Rinkel, E. Dolja, T. Schmitz, B. Nubbemeyer, T. H. Luu, J. S. Dickschat

Angew. Chem. Int. Ed. 2017, 56, 2776-2779.

  1. A detailed view on 1,8-cineol biosynthesis by Streptomyces clavuligerus

J. Rinkel, P. Rabe, L. zur Horst, J. S. Dickschat

Beilstein J. Org. Chem. 2016, 12, 2317-2324.

  1. Terpene Cyclases from Social Amoebae

P. Rabe, J. Rinkel, B. Nubbemeyer, T. G. Köllner, F. Chen, J. S. Dickschat

Angew. Chem. Int. Ed. 2016, 55, 15420-15423.

  1. Lessons from 1,3-Hydride Shifts in Sesquiterpene Cyclizations

J. Rinkel, P. Rabe, P. Garbeva, J. S. Dickschat

Angew. Chem. Int. Ed. 2016, 55, 13593-13596.

  1. Terpene synthase genes in eukaryotes beyond plants and fungi: Occurrence in social amoebae

X. Chen, T. G. Köllner, Q. Jia, A. Norris, B. Santhanam, P. Rabe, J. S. Dickschat, G. Shaulsky, J. Gershenzon, F. Chen

Proc. Natl. Acad. Sci. USA. 2016, 113, 12132-12137.

  1. Mechanistic investigations on six bacterial terpene cyclases

P. Rabe, T. Schmitz, J. S. Dickschat

Beilstein J. Org. Chem. 2016, 12, 1839-1850.

  1. The EIMS fragmentation mechanisms of the sesquiterpenes corvol ethers A and B, epi-cubebol and isodauc-8-en-11-ol

P. Rabe, J. S. Dickschat

Beilstein J. Org. Chem. 2016, 12, 1380-1394.

  1. Pristinol, a Sesquiterpene Alcohol with an Unusual Skeleton from Streptomyces pristinaespiralis

T. A. Klapschinski, P. Rabe, J. S. Dickschat

Angew. Chem. 2016, 128, 10296-10299; Angew. Chem. Int. Ed. 2016, 55, 10141-10144.

  1. Position-Specific Mass Shift Analysis: A Systematic Method for Investigating the EI-MS Fragmentation Mechanism of epi-Isozizaene

P. Rabe, T. A. Klapschinski, J. S. Dickschat

ChemBioChem 2016, 17, 1333-1337.

  1. Experimental and Theoretical Studies on Corvol Ether Biosynthesis

P. Rabe, A. Janusko, B. Goldfuss, J. S. Dickschat

ChemBioChem 2016, 17, 146-149.

  1. A method for investigating the stereochemical course of terpene cyclisations

P. Rabe, J. Rinkel, T. A. Klapschinski, L. Barra, J. S. Dickschat

Org. Biomol. Chem. 2016, 14, 158-164.

  1. Conformational Analysis, Thermal Rearrangement, and EI-MS Fragmentation Mechanism of (1(10)E,4E,6S,7R)-Germacradien-6-ol by 13C-Labeling Experiments

P. Rabe, L. Barra, J. Rinkel, R. Riclea, C. A. Citron, T. A. Klapschinski, A. Janusko, J. S. Dickschat

Angew. Chem. 2015, 127, 13649-13653; Angew. Chem. Int. Ed. 2015, 54, 13448-13451.

  1. Structures and Biosynthesis of Corvol Ethers—Sesquiterpenes from the Actinomycete Kitasatospora setae

P. Rabe, K. A. K. Pahirulzaman, J. S. Dickschat

Angew. Chem. 2015, 127, 6139-6143; Angew. Chem. Int. Ed. 2015, 54, 6041-6045.

  1. The chemical biology of dimethylsulfoniopropionate

J. S. Dickschat, P. Rabe, C. A. Citron

Org. Biomol. Chem. 2014, 13, 1954-1968.

  1. Synthesis of Isotopically Labelled Oligoprenyl Diphosphates and Their Application in Mechanistic Investigations of Terpene Cyclases

C. A. Citron, P. Rabe, L. Barra, C. Nakano, T. Hoshino, J. S. Dickschat

Eur. J. Org. Chem. 2014, 7684-7691.

  1. Synthesis and bioactivity of analogues of the marine antibiotic tropodithietic acid

P. Rabe, T. A. Klapschinski, N. L. Brock, C. A. Citron, P. D'Alvise, L. Gram, J. S. Dickschat

Beilstein J. Org. Chem. 2014, 10, 1796-1810.

  1. Induced-Fit Mechanism in Class I Terpene Cyclases

P. Baer,* P. Rabe,* K. Fischer, C. A. Citron, T. A. Klapschinski, M. Groll, J. S. Dickschat

Angew. Chem. 2014, 126, 7783-7787; Angew. Chem. Int. Ed. 2014, 53, 7652-7656.

  1. An Improved Technique for the Rapid Chemical Characterisation of Bacterial Terpene Cyclases

J. S. Dickschat, K. A. K. Pahirulzaman, P. Rabe, T. A. Klapschinski

ChemBioChem 2014, 15, 810-814.

  1. Hedycaryol Synthase in Complex with Nerolidol Reveals Terpene Cyclase Mechanism

P. Baer,* P. Rabe,* C. A. Citron, C. C. de Oliveira Mann, N. Kaufmann, M. Groll, J. S. Dickschat

ChemBioChem 2014, 15, 213-216.

  1. Halogenated volatiles from the fungus Geniculosporium and the actinomycete Streptomyces chartreusis

T. Wang, P. Rabe, C. A. Citron, J. S. Dickschat

 Beilstein J. Org. Chem. 2013, 9, 2767-2777.

  1. Volatile Terpenes from Actinomycetes: A Biosynthetic Study Correlating Chemical Analyses to Genome Data

P. Rabe, C. A. Citron, J. S. Dickschat

ChemBioChem 2013, 14, 2345-2354.

  1. Rapid Chemical Characterization of Bacterial Terpene Synthases

P. Rabe, J. S. Dickschat

Angew. Chem. 2013, 125, 1855-1857; Angew. Chem. Int. Ed. 2013, 52, 1810-1812.

  1. The Scent of Bacteria: Headspace Analysis for the Discovery of Natural Products

C. A. Citron, P. Rabe, J. S. Dickschat

J. Nat. Prod. 2012, 75, 1765-1776.

  1. The Stereochemical Course and Mechanism of the IspH Reaction

C. A. Citron, N. L. Brock, P. Rabe, J. S. Dickschat

Angew. Chem. 2012, 124, 4129-4133; Angew. Chem. Int. Ed. 2012, 51, 4053-4057.